Center for Functional Genomics
The Center for Functional Genomics at the Jacobs Neurological Institute conducts basic, clinical and translational research projects involving the genomics of neurological disease states, particularly multiple sclerosis and other autoimmune demyelinating disorders. The Center has a broad spectrum of expertise, personnel and equipment for pharmacological, molecular and cellular biology and genomic experiments in tissues from with neurological disorders. The Center is also actively involved in genetics, gene expression profiling and proteomics research and has a bioinformatics research program for analyzing large genomic data sets in the context of clinical data.
The Center is involved in several collaborative projects with Dr. Bianca Weinstock-Guttman and Dr. Robert Zivadinov that focus on the following areas of multiple sclerosis:
- Genomic mechanisms of drug effects in multiple sclerosis
- Molecular basis for partial responsiveness to interferon-beta
- Genetics of disease progression and treatment responsiveness in multiple sclerosis
- Clinical trials of immunomodulatory and neuroprotective agents in multiple sclerosis
